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Swallow the tablets with a glass of water  You may take the tablets either on an empty stomach or with food  Do not chew, break or crush the tablet, as it may result in overdose due to quick release of tapentadol in your body  The empty shell of the tablet may not be digested completely and thus be seen in stool  This should not worry you, since the drug (active substance) of the tablet has    Oct 10, 2026 · Tapentadol reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI) Tapentadol tablets are: • A strong prescription pain medicine that contains an opioid (narcotic) that is used to manage short term (acute) pain in adults, when other pain treatments such as non-opioid pain medicines do not treat your pain well enough or you cannot tolerate them Instruct patients to swallow NUCYNTA ER tablets whole; crushing, chewing, or dissolving NUCYNTA ER tablets can cause rapid release and absorption of a potentially fatal dose of tapentadol  Accidental Ingestion Accidental ingestion of even one dose of NUCYNTA ER, especially by children, can result in a fatal overdose of tapentadol Sep 14, 2026 · Tapentadol (brand name Nucynta and generics) is a strong opioid painkiller used to treat moderate to severe pain  Its three forms (immediate-release tablets, extended-release tablets, oral solution) are not interchangeable  Includes side effects, interactions, and uses Apr 21, 2018 · NUCYNTA® (tapentadol) tablets - GlobalRPH National Institutes of Health, U S  National Library of Medicine, DailyMed Database  Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA)  Please review the latest applicable package insert for additional information and possible updates  A local search option of this data can be found here Tapentadol is a prescription medicine used to treat moderate to severe pain and diabetic peripheral neuropathy